Cardiose®
Fuel performance with the power of citrus.
What is Cardiose®?
Cardiose® is a highly bioavailable, 100% natural extract from sweet oranges (Citrus sinensis), standardized in 2S-hesperidin, the biologically active form found in nature.
Cardiose® delivers measurable results across multiple areas of physical performance and metabolic health.
Benefits of Cardiose®
Cardiose® provides a combination of metabolic and performance benefits by acting on key physiological systems involved in blood flow and recovery. Its clinically supported profile makes it suitable for a wide range of applications in functional health and active nutrition.
Performance & Active Nutrition
- Increases aerobic and anaerobic performance
- Supports power output and endurance
- Supports faster recovery
Metabolic & Body Composition Support
- Promotes fat oxidation and metabolic efficiency
- Supports lean muscle development
- Helps maintain energy balance during exercise
Cellular Protection
- Helps reduce oxidative stress
- Supports a balanced inflammatory response
- Contributes to vascular and muscle integrity
How Cardiose® Works
Cardiose® acts on the vascular-muscular axis, a key system that influences performance and recovery.
After absorption, 2S-hesperidin metabolites stimulate endothelial nitric oxide synthase (eNOS), increasing nitric oxide production. This promotes vasodilation, allowing blood vessels to relax and improving the delivery of oxygen and nutrients to tissues.
In parallel, Cardiose® helps regulate oxidative stress and inflammation, supports mitochondrial function, and improves oxygen utilization in muscle. The result is a more efficient physiological response during exercise and recovery.
Additional Information about Cardiose®
- Clinically validated through 12 randomized, double-blind, placebo-controlled nutritional interventions
- Effective at a daily dose of 500 mg
- 100% natural ingredient with a solvent-free process
- US FDA no objection letter to our GRAS dossier (GRN 796), and not Novel in Food Supplements in the EU
- Suitable for functional health, sports nutrition, and healthy aging applications
For More Information about Cardiose®, Contact Us
If you are looking to develop differentiated products with clinically supported cardiovascular and performance benefits, our team is ready to help.
Contact HTBA to explore how Cardiose® can support your next product development.


